Ammonia → HCID 178424279, compound

HRID 1654873Notes

Reaction equation

HRID 1654873 reaction equation
[CH3:1][C:2]1[CH:26]=[CH:25][CH:24]=[CH:23][C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=S)=[N:8][CH:9]=[CH:10][CH:11]=1.[NH3:27]>>[CH3:1][C:2]1[CH:26]=[CH:25][CH:24]=[CH:23][C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=[NH:27])=[N:8][CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 20077040N-[3-(2-Methylbenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea

Product 1

HCID 178424279HCID 178424279, compound

Procedure

A mixture of N-[3-(2-methylbenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea (0.99 g, 0.0026 mol), yellow mercuric oxide (0.67 g, 0.003 mol) and methanolic ammonia solution (40 ml) was stirred at room temperature for 48 hours. The solvent was removed in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent and recrystallisation from acetonitrile gave the desired product. Yield 0.59 g (62%), m.p. 158°-159 ° C.

Workup

  1. customThe solvent was removed in vacuo
  2. filtrationfiltered hot
  3. customEvaporation of the solvent and recrystallisation from acetonitrile

Sources & evidence

ORD record
ord-e4e77b1212a94d3799820fc4db18d9c5
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

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