HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → N-[3-(2-Fluorobenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 4-Chlorophenyl isothiocyanate | HCID 16480 | — |
| Reactant | 2-Amino-3-(2-fluorobenzyloxy)pyridine | HCID 10242491 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | N-[3-(2-Fluorobenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea | HCID 20076963 | — |
Reaction Steps
A mixture of 2-amino-3-(2-fluorobenzyloxy)pyridine (1.98 g, 0.0091 mol), 4chlorophenyl isothiocyanate (1.83 g, 0.011 mol) and toluene (10 ml) was refluxed for 3.5 hours, cooled and treated with diethyl ether to induce crystallisation of the product. Yield 1.98 g (56%), m.p. 141°-143
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-df1b30e4633845fb8bf177c12c1bfeb2 |
| Source note | uspto-grants-1995_04 |