Ammonia → HCID 178425686, compound

HRID 1654879Notes

Reaction equation

HRID 1654879 reaction equation
[CH3:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][O:7][C:8]2[C:9]([NH:14][C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)=S)=[N:10][CH:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.[NH3:27]>>[CH3:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][O:7][C:8]2[C:9]([NH:14][C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)=[NH:27])=[N:10][CH:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 20076995HCID 20076995, compound

Product 1

HCID 178425686HCID 178425686, compound

Procedure

A mixture of yellow mercuric oxide (0.68 g, 0.0031 mol), N-[3-(4-methylbenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea (1.01 g, 0.0026 mol) and methanolic ammonia solution (40 ml) was stirred for 2 days at room temperature. The solvent was removed in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent and recrystallisation from acetonitrile gave the desired product. Yield 0.5 g (52%), m.p. 174°-175 ° C.

Workup

  1. customThe solvent was removed in vacuo
  2. filtrationfiltered hot
  3. customEvaporation of the solvent and recrystallisation from acetonitrile

Sources & evidence

ORD record
ord-2cf905df65444089a148da641eece209
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

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