Ammonia → HCID 178491291, compound

HRID 1654881Notes

Reaction equation

HRID 1654881 reaction equation
[CH3:1][O:2][C:3]1[CH:26]=[CH:25][C:6]([CH2:7][O:8][C:9]2[C:10]([NH:15][C:16]([NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=S)=[N:11][CH:12]=[CH:13][CH:14]=2)=[CH:5][CH:4]=1.[NH3:27]>>[CH3:1][O:2][C:3]1[CH:26]=[CH:25][C:6]([CH2:7][O:8][C:9]2[C:10]([NH:15][C:16]([NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[NH:27])=[N:11][CH:12]=[CH:13][CH:14]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 20076982N-[3-(4-Methoxybenzyloxy)pyrid-2-yl]-N'-phenylthiourea

Product 1

HCID 178491291HCID 178491291, compound

Procedure

A mixture of yellow mercuric oxide (1.51 g, 0.0069 mol), N-[3-(4-methoxybenzyloxy)pyrid-2-yl]-N'-phenylthiourea (2.14 g, 0.0058 mol) and methanolic ammonia solution (40 ml) was stirred for 2 days at room temperature. The solvent was removed in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent followed by trituration with ether and recrystallisation from acetonitrile gave the desired product. Yield 1.27 g (62%), m.p. 141°-143 ° C.

Workup

  1. customThe solvent was removed in vacuo
  2. filtrationfiltered hot
  3. customEvaporation of the solvent
  4. customfollowed by trituration with ether and recrystallisation from acetonitrile

Sources & evidence

ORD record
ord-f6120ef37e1c49c294ddaa86e4f53330
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

Loading…