HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → N-(3-(4-Methoxybenzyloxy)pyrid-2-yl)-N'-(4-chlorophenyl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 4-Chlorophenyl isothiocyanate | HCID 16480 | — |
| Reactant | 3-[(4-Methoxybenzyl)oxy]pyridin-2-amine | HCID 2728389 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | N-(3-(4-Methoxybenzyloxy)pyrid-2-yl)-N'-(4-chlorophenyl)thiourea | HCID 20076976 | — |
Reaction Steps
A mixture of 2-amino-3-(4-methoxybenzyloxy)pyridine (1.80 g, 0.0078 mol), 4chlorophenyl isothiocyanate (1.58 g, 0.0094 mol) and toluene (10 ml) was refluxed for 3.5 hours, then cooled and treated with diethyl ether to induce crystallisation of the product. Yield 2.2 g (70.5%), m.p. 136°-138 ° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-1db6ed41fc37437e83c0fec0424c0677 |
| Source note | uspto-grants-1995_04 |