HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → N-[3-(2-Fluoro-6-chlorobenzyloxy)pyrid-2-yl]-N'-phenylthiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Phenyl Isothiocyanate | HCID 7673 | — |
| Reactant | 2-Amino-3-(2-chloro-6-fluorobenzyloxy)pyridine | HCID 10106270 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | N-[3-(2-Fluoro-6-chlorobenzyloxy)pyrid-2-yl]-N'-phenylthiourea | HCID 20077023 | — |
Reaction Steps
A mixture of 2-amino-3-(2-fluoro-6-chlorobenzyloxy)pyridine (7.6 g, 0.03 mol), phenyl isothiocyanate (3.95 ml, 0.033 mol) and toluene (25 ml) was refluxed for 2.5 hours, then cooled and treated with diethyl ether to induce crystallisation of the product. Yield 8.47 g (73%), m.p. 143°-145 ° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-4416825623b449e1b1d9a0b01589dfe6 |
| Source note | uspto-grants-1995_04 |