Ammonia → HCID 178511999, compound

HRID 1654888Notes

Reaction equation

HRID 1654888 reaction equation
[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=S)=[N:8][CH:9]=[CH:10][CH:11]=1.[NH3:27]>>[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[NH:27])=[N:8][CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 20077023N-[3-(2-Fluoro-6-chlorobenzyloxy)pyrid-2-yl]-N'-phenylthiourea

Product 1

HCID 178511999HCID 178511999, compound

Procedure

A mixture of N-[3-(2-fluoro-6-chlorobenzyloxy)pyrid-2-yl]-N'-phenylthiourea (2 g, 0.0052 mol), yellow mercuric oxide (1.34g, 0.0062 mol) and methanolic ammonia solution (40 ml) was stirred for 72 hours. The solvent was removed in vacuo and the black residue was treated with chloroform and filtered through celite. Evaporation of the solvent and recrystallisation from acetonitrile gave the desired product. Yield 1.07 g (56%), m.p. 147°-149 ° C.

Workup

  1. customThe solvent was removed in vacuo
  2. additionthe black residue was treated with chloroform
  3. filtrationfiltered through celite
  4. customEvaporation of the solvent and recrystallisation from acetonitrile

Sources & evidence

ORD record
ord-cf59eff3d0064a44b3541690b4f1d207
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

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