Ammonia → HCID 178512026, compound

HRID 1654890Notes

Reaction equation

HRID 1654890 reaction equation
[F:1][C:2]1[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=S)=[N:8][CH:9]=[CH:10][CH:11]=1.[NH3:28]>>[F:1][C:2]1[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=[NH:28])=[N:8][CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 20076944N-[3-(2-Fluoro-6-chlorobenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea

Product 1

HCID 178512026HCID 178512026, compound

Procedure

A mixture of N-[3-(2-fluoro-6-chlorobenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea (2 g, 0.0047 mol), yellow mercuric oxide (2.56 g, 0.012 mol) and methanolic ammonia solution (40 ml) was stirred for 40 hours. The solvent was removed in vacuo and the black residue was treated with chloroform and filtered through celite. Evaporation of the solvent and recrystallisation from chloroform/ether gave the desired product. Yield 0.96 g (50%), m.p. 168°-170 ° C.

Workup

  1. customThe solvent was removed in vacuo
  2. additionthe black residue was treated with chloroform
  3. filtrationfiltered through celite
  4. customEvaporation of the solvent and recrystallisation from chloroform/ether

Sources & evidence

ORD record
ord-63499fbc1d624dcf887676aa61c94c6f
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

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