HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → N-[3-(2-Chloro-6-fluorobenzyloxy)pyrid-2-yl]-N'-(2-fluorophenyl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 2-Fluorophenyl isothiocyanate | HCID 97520 | — |
| Reactant | 2-Amino-3-(2-chloro-6-fluorobenzyloxy)pyridine | HCID 10106270 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | N-[3-(2-Chloro-6-fluorobenzyloxy)pyrid-2-yl]-N'-(2-fluorophenyl)thiourea | HCID 20076947 | — |
Reaction Steps
A mixture of 2-amino-3-(2-chloro-6-fluorobenzyloxy)pyridine (7.48g, 0.03 mol), 2fluorophenyl isothiocyanate (5.0 g, 0.033 mol) and toluene (30 ml) was heated under reflux for 1.5 hours, then cooled and diluted with ether to induce crystallisation of the product. Yield 7.9 g (59 %), m.p. 145°-147 ° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-761b22b4275b429f839604821279b0a2 |
| Source note | uspto-grants-1995_04 |