Ammonia → HCID 178511985, compound

HRID 1654892Notes

Reaction equation

HRID 1654892 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[F:22])=S)=[N:8][CH:9]=[CH:10][CH:11]=1.[NH3:28]>>[Cl:1][C:2]1[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[F:22])=[NH:28])=[N:8][CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 20076947N-[3-(2-Chloro-6-fluorobenzyloxy)pyrid-2-yl]-N'-(2-fluorophenyl)thiourea

Product 1

HCID 178511985HCID 178511985, compound

Procedure

A mixture of yellow mercuric oxide (4.13g, 0.019 mol), N-[3-(2-chloro-6-fluoro -benzyloxy)pyrid-2-yl]-N'-(2-fluorophenyl)thiourea (3.10g, 0.0076 mol) and methanolic ammonia solution (60 ml) was stirred for 24 hours at room temperature. The mixture was filtered through celite and the filtrate evaporated to a yellow solid, which was recrystallised from ethyl acetate/pet. ether. Yield 1.51 g (51%), m.p 138°-140 ° C.

Workup

  1. filtrationThe mixture was filtered through celite
  2. customthe filtrate evaporated to a yellow solid, which
  3. customwas recrystallised from ethyl acetate/pet. ether
  4. customYield 1.51 g (51%), m.p 138°-140 ° C.

Sources & evidence

ORD record
ord-0f6dd58aabf24f4288ca3268701b4eb8
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

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