反应详情

A mixture of yellow mercuric oxide (4.13g, 0.019 mol), N-[3-(2-chloro-6-fluoro -benzyloxy)pyrid-2-yl]-N'-(2-fluorophenyl)thiourea (3.10g, 0.0076 mol) and methanolic ammonia solution (60 ml) was stirred for 24 hours at room temperature. The mixture was filtered through celite and the filtrate evaporated to a yellow solid, which was recrystallised from ethyl acetate/pet. ether. Yield 1.51 g (51%), m.p 138°-140 ° C.

1. filtrationThe mixture was filtered through celite
2. customthe filtrate evaporated to a yellow solid, which
3. customwas recrystallised from ethyl acetate/pet. ether
4. customYield 1.51 g (51%), m.p 138°-140 ° C.