Ammonia → HCID 178512055, compound

HRID 1654894Notes

Reaction equation

HRID 1654894 reaction equation
[Cl:1][C:2]1[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=2)=S)=[N:8][CH:9]=[CH:10][CH:11]=1.[NH3:30]>>[Cl:1][C:2]1[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=2)=[NH:30])=[N:8][CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 20077035N-[3-(2-chloro-6 fluorobenzyloxy)pyrid-2-yl]-N'-(4-nitrophenyl)thiourea

Product 1

HCID 178512055HCID 178512055, compound

Procedure

A mixture of yellow mercuric oxide (1.26g, 0.006 mol), N-[3-(2-chloro-6 fluorobenzyloxy)pyrid-2-yl]-N'-(4-nitrophenyl)thiourea (2.08g, 0.005 mol) and methanolic ammonia solution (40 ml) was stirred for 24 hours at room temperature, then heated under reflux for 30 min. The solvent was removed in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent and recrystallisation from ethanol gave the desired product. Yield 1.16 g (58%), m.p 180°-182 ° C.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 30 min
  3. customThe solvent was removed in vacuo
  4. filtrationfiltered hot
  5. customEvaporation of the solvent and recrystallisation from ethanol

Sources & evidence

ORD record
ord-b609fb7c5db344da856460cb9351c7e0
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

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