HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → N-[3-(2-chloro-6-fluorobenzyloxy)pyrid-2-yl]-N'-4-methylphenylthiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | p-Tolyl isothiocyanate | HCID 12149 | — |
| Reactant | 2-Amino-3-(2-chloro-6-fluorobenzyloxy)pyridine | HCID 10106270 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | N-[3-(2-chloro-6-fluorobenzyloxy)pyrid-2-yl]-N'-4-methylphenylthiourea | HCID 20076981 | — |
Reaction Steps
A mixture of 2-amino-3-(2-chloro-6-fluorobenzyloxy)pyridine (2g, 0.008 mol), 4methylphenyl isothiocyanate (1.43g, 0.0096 mol) and toluene (10 ml) was heated under reflux for 5 hours, then cooled and diluted with ether to induce crystallisation of the product. Yield 2.61g (82%) m.p. 138°-140 ° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-599005b0501a4dc7bc0d9d1544590ab3 |
| Source note | uspto-grants-1995_04 |