Ammonia → HCID 178512049, compound

HRID 1654898Notes

Reaction equation

HRID 1654898 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)=S)=[N:8][CH:9]=[CH:10][CH:11]=1.[NH3:28]>>[Cl:1][C:2]1[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)=[NH:28])=[N:8][CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 20077006N-[3-(2-chloro-6-fluorobenzyloxy)pyrid-2-yl]-N'-4-fluorophenylthiourea

Product 1

HCID 178512049HCID 178512049, compound

Procedure

A mixture of yellow men:uric oxide (0.65g, 0.003 mol), N-[3-(2-chloro-6-fluorobenzyloxy)pyrid-2-yl]-N'-4-fluorophenylthiourea (1 .0g, 0.0025 mol) and methanolic ammonia solution (30 ml) was stirred for 3 days at room temperature. The solvent was removed in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent followed by recrystallisation from ethanol gave the desired product. Yield 0.38 g, (40%), m.p. 152°-154 ° C.

Workup

  1. additionA mixture of yellow men
  2. customThe solvent was removed in vacuo
  3. filtrationfiltered hot
  4. customEvaporation of the solvent
  5. customfollowed by recrystallisation from ethanol

Sources & evidence

ORD record
ord-8b52ad54b98c454a88f1cb9cf5fb3b36
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

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