反应详情

A mixture of 2-amino-3-(2,6-dichlorobenzyloxy)pyridine (5 g, 0.018 mol), 4-chlorophenyl isothiocyanate (3.76 g, 0.022 mol) and toluene (20 ml) was heated under reflux for 3 hours, then cooled and diluted with ether to induce crystallisation of the product, which was recrystallised from ethanol/ether. Yield 6.69 g (82%), m.p. 179°-180 ° C.

1. temperaturewas heated
2. temperatureunder reflux for 3 hours
3. temperaturecooled
4. customcrystallisation of the product, which
5. customwas recrystallised from ethanol/ether