Ammonia → HCID 178512000, compound

HRID 1654905Notes

Reaction equation

HRID 1654905 reaction equation
[F:1][C:2]1[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19](Cl)=[CH:18][CH:17]=2)=S)=[N:8][CH:9]=[CH:10][CH:11]=1.[NH3:28]>>[F:1][C:2]1[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[NH:28])=[N:8][CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 20076950N-[3-(2,6-Difluorobenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea

Product 1

HCID 178512000HCID 178512000, compound

Procedure

A mixture of yellow mercuric oxide. (0.75g, 0.0034mol), N-[3-(2-,6-difluorobenzyloxy)pyrid-2-yl]-N'-4-chlorophenylthiourea (1.11 g, 0.003mol) and methanolic ammonia solution (40 ml) was stirred for 15 hours at room temperature. The solvent was removed in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent followed by recrystallisation from ethanol gave the desired product. Yield 0.54 g (51%),m.p. 136°-137 ° C.

Workup

  1. customThe solvent was removed in vacuo
  2. filtrationfiltered hot
  3. customEvaporation of the solvent
  4. customfollowed by recrystallisation from ethanol

Sources & evidence

ORD record
ord-be2d86da163c42cb8fea26e13dd510f6
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

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