HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → N-[3-(2,6-Difluorobenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 4-Chlorophenyl isothiocyanate | HCID 16480 | — |
| Reactant | 3-(2,6-Difluoro-benzyloxy)-pyridin-2-ylamine | HCID 10263498 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | N-[3-(2,6-Difluorobenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea | HCID 20076950 | — |
Reaction Steps
A mixture of 2-amino-3-(2,6-difluorobenzyloxy)pyridine (2.10 g, 0.009 mol), 4-chlorophenyl isothiocyanate (1.81 g, 0.01 mol) and toluene (10 ml) was refluxed for 3 hours, then cooled and treated with diethyl ether to induce crystallisation of the product. Yield 2.71 g (75%), m.p. 151°-154 ° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-305126df7ec149e78f531bbebad37242 |
| Source note | uspto-grants-1995_04 |