HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → N-(3-(2,3,6-Trifluorobenzyloxy)pyrid-2-yl)-N'-(4-chlorophenyl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 4-Chlorophenyl isothiocyanate | HCID 16480 | — |
| Reactant | 2-Amino-3-(2,3,6-trifluorobenzyloxy)pyridine | HCID 20076969 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | N-(3-(2,3,6-Trifluorobenzyloxy)pyrid-2-yl)-N'-(4-chlorophenyl)thiourea | HCID 20077029 | — |
Reaction Steps
A mixture of 2-amino-3-(2,3,6-trifluorobenzyloxy)pyridine (2.00 g, 0.0078 mol), 4chlorophenyl isothiocyanate (1.6 g, 0.094 mol) and toluene (10 ml) was refluxed for 3 hours, then cooled and treated with diethyl ether to induce crystallisation of the product. Yield 2.82 g (85.5%), m.p.174°-176 ° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-225818c2f318416d965c6de32df4c96b |
| Source note | uspto-grants-1995_04 |