Ammonia → HCID 178512028, compound

HRID 1654915Notes

Reaction equation

HRID 1654915 reaction equation
[F:1][C:2]1[C:26]([F:27])=[CH:25][CH:24]=[C:23]([F:28])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=S)=[N:8][CH:9]=[CH:10][CH:11]=1.[NH3:29]>>[F:1][C:2]1[C:26]([F:27])=[CH:25][CH:24]=[C:23]([F:28])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=[NH:29])=[N:8][CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 20077029N-(3-(2,3,6-Trifluorobenzyloxy)pyrid-2-yl)-N'-(4-chlorophenyl)thiourea

Product 1

HCID 178512028HCID 178512028, compound

Procedure

A mixture of yellow mercuric oxide (1.23g, 0,056 mol), N-[3-(2,3,6-trifluorobenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea (2.00g 0.0047mol) and methanolic ammonia solution (40 ml) was stirred for 1 day at room temperature. The solvent was removed in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent, trituration with ether and recrystallisation from acetonitrile gave the desired product. Yield 1.20 g (63%), m.p. 153°-156 ° C.

Workup

  1. customThe solvent was removed in vacuo
  2. filtrationfiltered hot
  3. customEvaporation of the solvent, trituration
  4. customwith ether and recrystallisation from acetonitrile

Sources & evidence

ORD record
ord-5551d158a425474696bcc91636298605
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

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