HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → N-[3-(3-chloro-2-fluorobenzyloxy)pyrid-2-yl]-N'-4-chlorophenylthiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 4-Chlorophenyl isothiocyanate | HCID 16480 | — |
| Reactant | 2-Amino-3-(3-chloro-2-fluorobenzyloxy)pyridine | HCID 10399991 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | N-[3-(3-chloro-2-fluorobenzyloxy)pyrid-2-yl]-N'-4-chlorophenylthiourea | HCID 20077003 | — |
Reaction Steps
A mixture of 2-amino-3-(3-chloro-2-fluorobenzyloxy)pyridine (2.00 g, 0.0079 mol), 4chlorophenyl isothiocyanate (1.61 g, 0.0095 mol) and toluene (10 ml) was refluxed for 3 hours, then cooled and treated with diethyl ether to induce crystallisation of the product. Yield2.37 g (71%),m.p. 174°-176 ° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-d47206c9f3a44cb6b416a5b5269076b4 |
| Source note | uspto-grants-1995_04 |