HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 10082660, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Amino-3-Hydroxypyridine | HCID 28114 | — |
| Reactant | Benzene, 1-(bromomethyl)-2-fluoro-3-methyl- | HCID 519062 | — |
| Catalyst | Trioctylmethylammonium chloride | HCID 21218 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 10082660 | HCID 10082660 | — |
Reaction Steps
A mixture of 2-amino-3-hydroxypyridine (2.8 g, 0.026 mol), dichloromethane (20 ml) and 40% aqueous sodium hydroxide solution (20 ml) was stirred for five minutes, then 2-fluoro-3-methylbenzyl bromide (5.0 g, 0.026 mol) and Adogen 464 (3 ml) were added and stirring continued for 16 hours. The mixture was diluted with water and extracted with dichloromethane. Drying and evaporation of the organic extracts, and trituration with ether gave the desired product. Yield 3.99 g (66%), m.p. 115°-118 ° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-2329a15a3eaa4c0a94fff01766267128 |
| Source note | uspto-grants-1995_04 |