HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 20077026, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 4-Chlorophenyl isothiocyanate | HCID 16480 | — |
| Reactant | HCID 10082660 | HCID 10082660 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 20077026 | HCID 20077026 | — |
Reaction Steps
A mixture of 2-amino-3-(2-fluoro-3-methylbenzyloxy)pyridine (2.00 g, 0.0086 mol), 4chlorophenyl isothiocyanate (1.75 g, 0.0103 mol) and toluene (10 ml) was refluxed for 3 hours, then cooled and treated with diethyl ether to induce crystallisation of the product. Yield 3.21g (93%), m.p. 184°-187 ° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-ff76b5228d7841ebab05504148834325 |
| Source note | uspto-grants-1995_04 |