Ammonia → HCID 178425265, compound

HRID 1654924Notes

Reaction equation

HRID 1654924 reaction equation
[F:1][C:2]1[C:26]([CH3:27])=[CH:25][CH:24]=[CH:23][C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=S)=[N:8][CH:9]=[CH:10][CH:11]=1.[NH3:28]>>[F:1][C:2]1[C:26]([CH3:27])=[CH:25][CH:24]=[CH:23][C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=[NH:28])=[N:8][CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 20077026HCID 20077026, compound

Product 1

HCID 178425265HCID 178425265, compound

Procedure

A mixture of yellow mercuric oxide (1.29 g, 0.0059 mol), N-[3-(2-fluoro-3-methylbenzyloxy)pyrid-2-yl]-N'-4-chlorophenylthiourea (2.0g, 0.0049 mol) and methanolic ammonia solution (40 ml) was stirred for 2 days at room temperature. The solvent was removed in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent followed by trituration with ether and recrystallisation from acetonitrile gave the desired product. Yield 1.59g, (84.5%), m.p. 179°-181 ° C.

Workup

  1. customThe solvent was removed in vacuo
  2. filtrationfiltered hot
  3. customEvaporation of the solvent
  4. customfollowed by trituration with ether and recrystallisation from acetonitrile

Sources & evidence

ORD record
ord-dc48e16fbaa943788cea752f38fc1a94
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

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