Ammonia → HCID 178425266, compound

HRID 1654927Notes

Reaction equation

HRID 1654927 reaction equation
[CH3:1][C:2]1[CH:26]=[C:25]([CH3:27])[CH:24]=[C:23]([CH3:28])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=S)=[N:8][CH:9]=[CH:10][CH:11]=1.[NH3:29]>>[CH3:1][C:2]1[CH:26]=[C:25]([CH3:27])[CH:24]=[C:23]([CH3:28])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=[NH:29])=[N:8][CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 20076929HCID 20076929, compound

Product 1

HCID 178425266HCID 178425266, compound

Procedure

A mixture of yellow mercuric oxide (0.95 g, 0.0044 mol), N-[3-(2,4,6-trimethylbenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea (1.5 g, 0.0036 mol) and methanolic ammonia solution (40 ml) was stirred for 2 days at room temperature. The solvent was removed in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent followed by trituration with ether and recrystallisation from acetonitrile gave the desired product. Yield 1.16 g (82%), m.p. 169°-171 ° C.

Workup

  1. customThe solvent was removed in vacuo
  2. filtrationfiltered hot
  3. customEvaporation of the solvent
  4. customfollowed by trituration with ether and recrystallisation from acetonitrile

Sources & evidence

ORD record
ord-f73492e1e4c34692b6a777f21939c760
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

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