HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 20076938, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 4-Chlorophenyl isothiocyanate | HCID 16480 | — |
| Reactant | 2-Amino-3-(2-chloro-6-fluorobenzyloxy)-5-chloropyridine | HCID 20077060 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 20076938 | HCID 20076938 | — |
Reaction Steps
A mixture of 2-amino-3-(2-chloro-6-fluorobenzyloxy)-5-chloropyridine (0.82 g, 0.0028 mol), 4-chlorophenyl isothiocyanate (0.56 g, 0.0033 mol) and toluene (10 ml) was heated under reflux for 16 hours, then cooled and diluted with ether to induce crystallisation of the product, which was triturated with ethanol. Yield 0.68 g (54%), m.p. 158°-160 ° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-1f23fc8c37ec40be860f58665ec56d7b |
| Source note | uspto-grants-1995_04 |