HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → N-[3-(2-chloro-6-fluorobenzyloxy)-6-methylpyrid-2-yl]-N'-4-chlorophenylthiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 4-Chlorophenyl isothiocyanate | HCID 16480 | — |
| Reactant | 2-Amino-3-(2-chloro-6-fluorobenzyloxy)-6-methylpyridine | HCID 20076974 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | N-[3-(2-chloro-6-fluorobenzyloxy)-6-methylpyrid-2-yl]-N'-4-chlorophenylthiourea | HCID 20076972 | — |
Reaction Steps
A mixture of 2-amino-3-(2-chloro-6-fluorobenzyloxy)-6-methylpyridine (2.0 g, 0.0075 mol), 4-chlorophenyl isothiocyanate (1.53 g, 0.0089 mol) and toluene (10 ml) was heated under reflux for 2 hours, then cooled and diluted with ether to induce crystallisation of the product, which was triturated with ethanol. Yield 2.6 g (82%), m.p. 204°-205 ° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-c56c04eaad2e475b9918b67ad67095a6 |
| Source note | uspto-grants-1995_04 |