Benzyl Alcohol → HCID 20077190, compound

Participants

Reaction Steps

11.2 g (42.8 mmol) of [5-(ethoxycarbonylmethyl)indan-2-yl]acetic acid and 6.5 ml (46.7 mmol) triethylamine were dissolved in 140 ml toluene, to which was added 14.1 g (51.4 mmol) of diphenylphosphorylazide, followed by stirring for 30 minutes at room temperature. Subsequently, 5.05 g (46.7 mmol) of benzyl alcohol was added and refluxed for 14 hours. After cooling, the reaction mixture was washed with 1N hydrochloric acid, water, 1N sodium hydroxide and water in this order and dried. The solvent was distilled off and the residue was purified by silica gel column chromatography (chloroform) to obtain 12.7 g colorless solid. Yield: 81%

Provenance & Evidence