Sodium Hydroxide → HCID 15290037, compound

HRID 1654947Notes

Reaction equation

HRID 1654947 reaction equation
C([O:3][C:4](=[O:26])[CH2:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[CH2:11][CH:10]([CH2:15][NH:16][S:17]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)(=[O:19])=[O:18])[CH2:9]2)C.[OH-].[Na+]>CO>[C:20]1([S:17]([NH:16][CH2:15][CH:10]2[CH2:9][C:8]3[C:12](=[CH:13][CH:14]=[C:6]([CH2:5][C:4]([OH:26])=[O:3])[CH:7]=3)[CH2:11]2)(=[O:19])=[O:18])[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20077192HCID 20077192, compound

Product 1

HCID 15290037HCID 15290037, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

844 mg (2.26 mmol) of ethyl[2-(phenylsulfonylaminomethyl)-indan-5-yl]acetate was dissolved in 3 ml of methanol, to which was added 5 ml of 1N sodium hydroxide and stirred for 1 hour at room temperature. Methanol was removed and the aqueous phase was washed with chloroform, and added with 1N hydrochloric acid for making the system acidic. The precipitates were extracted with ethyl acetate, dried and condensed. The residue was recrystallized from ethyl acetate to obtain 679 mg crystals. Yield: 87%

Workup

  1. customMethanol was removed
  2. washthe aqueous phase was washed with chloroform
  3. additionadded with 1N hydrochloric acid
  4. extractionThe precipitates were extracted with ethyl acetate
  5. customdried
  6. customcondensed
  7. customThe residue was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-4f95c644b88948d3babef96605a98c7f
Source dataset
uspto-grants-1995_04
Patent number
US05409956

Reaction notes

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