Ethyl bromoacetate → HCID 20077201, compound

Participants

Reaction Steps

1.85 g (6.20 mmol) of 2-(t-butoxycarbonylaminomethyl)5-hydroxyindan was dissolved in 20 ml of acetone, to which were added 1.52 g (11.0 mmol) of potassium carbonate and 1.10 g (6.60 mmol) of ethyl bromoacetate, and refluxed for 3.5 hours. After cooling, the precipitates were filtrated, and the residue obtained by condensing the filtrate was purified by silica gel column chromatography (ethyl acetate:hexane=1:2) to obtain 1.90 g of colorless crystals. Yield: 80%

Provenance & Evidence