Water → HCID 20077199, compound

Participants

Reaction Steps

1.77 g (5.00 mmol) of ethyl[2-(t-butoxycarbonylaminomethyl)-indan-5-oxy]acetate was dissolved in 6 ml of methylene chloride, to which was added 4 ml of trifluoroacetic acid under ice-cooling and stirred for 1 hour. The reaction mixture was diluted with 40 ml of methylene chloride. A solution of 40 ml water containing 8.37 g (60 mmol) of potassium carbonate was added thereto and stirred vigorously. 10 minutes after, 1.07 g (6.00 mmol) of phenylsulfonylchloride was added thereto, and stirred for further 1.5 hours. The organic phase was collected, dried and condensed, and the residue was purified by column gel chromatography (ethyl acetate:hexane=1:1) to obtain 1.68 g of a colorless oil. Yield: 88%

Provenance & Evidence