反应详情

369 mg (1.15 mmol) of 2-[(4-chlorophenyl)sulfonylaminomethyl)indan was dissolved in 5 ml of methylene chloride, to which were added 460 mg (4.20 mmol) of anhydrous aluminum chloride under ice-cooling and then 302 mg (3.80 mmol) of acetyl chloride dropwise. After stirring for 30 minutes at the same temperature, the reaction solution was admixed with ice, and the organic phase was washed with water and saturated-aqueous sodium bicarbonate, dried and the solvent was removed. The residue was recrystallized from a solvent mixture of ethyl acetate and isopropylether to obtain 310 mg of colorless crystals. Yield: 75%

1. temperaturecooling
2. washthe organic phase was washed with water and saturated-aqueous sodium bicarbonate
3. customdried
4. customthe solvent was removed
5. customThe residue was recrystallized from a solvent mixture of ethyl acetate and isopropylether