Sodium borohydride → HCID 18921518, compound

Participants

Reaction Steps

4.46 g of ethyl 3-[2-[(4-chlorophenyl)sulfonylaminomethyl]indan-5-yl]-3-oxopropionate obtained in Step 1 of Example 46 was dissolved in 60 ml of ethanol, to which 193 mg of sodium borohydride was added under ice-cooling, followed by stirring for 2 hours at the same temperature. Subsequently, the solvent was distilled off under reduced pressure. The residue was added with ethyl acetate, washed with water and dried. The solvent was removed under reduced pressure. The residue was recrystallized from a solvent mixture of ethyl acetate and isopropyl ether to obtain 4.37 g of colorless crystals. Yield: 99%

Provenance & Evidence