1,3-Propanediamine → HCID 20077430, compound

Participants

Reaction Steps

To a stirred solution of 1,3-propanediamine (0.37 g, 0.005 mol) in dry benzene (25) mL) was added dropwise at room temperature pyridine-2-carboxaldehyde (2) (0.535 g. 0.005 mol) in dry benzene (5 mL). The resulting cloudy solution was heated under reflux, using a Dean-Stark trap to remove water during 2 hr. The solvent was then completely removed by distillation to give about a quantatitive yield (0.80 g) of compound (9), having an N--CH(2-pyr)--N resonance at 4.1 ppm).

Provenance & Evidence