HCID 135689355, compound → HCID 135689354, compound

Participants

Reaction Steps

A solution of 4-hydroxy-3-(3-nitrophenyl)-2(5H)-thiophenone (0.36 g, 1.5 mmol) in ethanol (70 ml) was hydrogenated at 40 psi using a palladium on carbon catalyst (200 mg, 55% (w /w)), for 10 min. The catalyst was filtered off and the solvent evaporated in vacuo. The brown residue was triturated with ether (10 ml) and methanol (0.5 ml). 3-(3-Aminophenyl)-4-hydroxy-2(5H)-thiophenone (208 mg, 67%) was isolated as a beige solid. mp 252°-254° C. (dec.). 1H NMR (360MHz, D6 -DMSO) δ3.88 (2H, s), 6.56 (1H, d, J=8Hz), 7.05 (1H, dd, J=8 and 8Hz), 7.13 (1H, d, J =8Hz), 7.21 (1H, s).

Provenance & Evidence