HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl benzoylacetate → N-(3-methoxyphenyl)-3-oxo-3-phenylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl benzoylacetate | HCID 7170 | — |
| Reactant | 3-Methoxyaniline | HCID 10824 | — |
| Catalyst | Pyridine | HCID 1049 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | N-(3-methoxyphenyl)-3-oxo-3-phenylpropanamide | HCID 699437 | — |
Reaction Steps
A solution of m-anisidine (10 g), ethyl benzoylacetate (19 g) and pyridine (2 drops) in xylene (20 mL) was heated to reflux for 5 hr. The mixture was cooled to r.t. and concentrated. The residual material was subjected to chromatography (silica gel; hexane/EtOAc (4:1)), affording the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05410054 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-acfcda78abe34017b420033738ea57e6 |
| Source note | uspto-grants-1995_04 |