Phosphoric Acid → 7-methoxy-4-phenyl-quinolin-2-ol

Participants

Reaction Steps

A mixture of N-(3-methoxyphenyl)benzoylacetamide (5.8 g), o-phosphoric acid (30 mL of 85% acid in H2O) and H2O (30 mL) was heated at 100°-110° C. for 6 hr. After cooling to r.t., H2O (50 mL) was added and the precipitate that formed was collected by filtration. The title compound was thus obtained as a mixture with the regioisomeric product, 5-methoxy-4-phenyl-2-quinolinone, and used as such.

Provenance & Evidence