Imidazole → HCID 20077469, compound

Participants

Reaction Steps

A mixture of 7-hydroxy-4-phenylquinoline (366 mg), tert-butyldimethylsilyl chloride (200 mg) and imidazole (282 mg) in DMF (2 mL) was stirred at r.t. for 17 hr and then diluted with 5% aq. NaHCO3 (20 mL). The mixture was extracted with EtOAc (3×) and the combined organics were washed with H2O (3×), brine, dried (MgSO4) and concentrated. Flash chromatography of the residue (silica gel; EtOAc/hexane (15:85)) provided the title compound as a solid.

Provenance & Evidence