2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → HCID 20077445, compound

Participants

Reaction Steps

A mixture of 3-carbomethoxy-6-methoxy-1-phenyl-3,4-dihydro-isoquinoline (257 mg) and DDQ (217 mg) in benzene (35 mL) was heated at reflux for 1 hr. the mixture was cooled to r.t., filtered through celite washing with toluene and the filtrate was concentrated. Flash chromatography of the residue (silica gel; toluene/EtOAc (85:15)) provided the title compound as a solid.

Provenance & Evidence