HRID1655115

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7918

Acetic anhydride

C4H6O3

结构：CCCCc1nc2c(n1Cc1ccc(-c3ccccc3C(=O)OC)cc1)C(C(=O)OC)NCC2

HCID15291720

未命名化合物

PRODUCTS

生成物

结构：CCCCc1nc2c(n1Cc1ccc(-c3ccccc3C(=O)OC)cc1)C(C(=O)OC)N(C(C)=O)CC2

HCID22414712

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

To a mixture of the compound obtained in Example 12 (1.70 g) and pyridine (20 ml) is added acetic anhydride (5 ml), and the mixture is stirred overnight. The solvent is distilled off, and to the resulting residue is added chloroform, and the mixture is washed, dried, and evaporated to remove the solvent. The residue is purified by silica gel column chromatography (solvent; chloroform/ethanol=10.1) to give methyl 2-n-butyl-5-acetyl-3-(2'-methoxycarbonylbiphenyl-4-yl)methyl-4,5,6,7-tetrahydroimidazo[4,5 -c]pyridine-4-carboxylate (0.47 g) as an oil.

WORKUP

后处理

distillationThe solvent is distilled off
additionto the resulting residue is added chloroform
washthe mixture is washed
customdried
customevaporated
customto remove the solvent
customThe residue is purified by silica gel column chromatography (solvent; chloroform/ethanol=10.1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a643af08d4e6437cb128db33ab39c75d
来源数据集: uspto-grants-1995_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05409936
来源说明: uspto-grants-1995_04

反应 SMILES

[CH2:1]([C:5]1[N:17]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]([O:33][CH3:34])=[O:32])=[CH:21][CH:20]=2)[C:8]2[CH:9]([C:13]([O:15][CH3:16])=[O:14])[NH:10][CH2:11][CH2:12][C:7]=2[N:6]=1)[CH2:2][CH2:3][CH3:4].[C:35](OC(=O)C)(=[O:37])[CH3:36]>N1C=CC=CC=1>[CH2:1]([C:5]1[N:17]([CH2:18][C:19]2[CH:20]=[CH:21][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]([O:33][CH3:34])=[O:32])=[CH:23][CH:24]=2)[C:8]2[CH:9]([C:13]([O:15][CH3:16])=[O:14])[N:10]([C:35](=[O:37])[CH3:36])[CH2:11][CH2:12][C:7]=2[N:6]=1)[CH2:2][CH2:3][CH3:4]