HRID1655120

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID62324

Propanoyl chloride

C3H5ClO

结构：CCCc1nc2c(n1Cc1ccc(-c3ccccc3)c(C(=O)OC(C)(C)C)c1)C(C(=O)OCC)NCC2.O=C(O)C(=O)O

HCID20076809

未命名化合物

PRODUCTS

生成物

结构：CCCc1nc2c(n1Cc1ccc(-c3ccccc3C(=O)OC(C)(C)C)cc1)C(C(=O)OCC)N(C(=O)CC)CC2

HCID19932984

未命名化合物

收率 174%

PROCEDURE

实验过程

The compound obtained in Example 62 (1.0 g) is treated in the same manner as in Example 64 with using propionyl chloride (0.23 g) instead of acetic anhydride to give ethyl 2-n-propyl-5-propionyl-3-[2'-(t-butoxycarbonyl)biphenyl-4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]-pyridine-4-carboxylate (0.82 g) as a white foam.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-081ce939b8c4497dbfc741c6bce1b87b
来源数据集: uspto-grants-1995_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05409936
来源说明: uspto-grants-1995_04

反应 SMILES

[C:1](O)(=O)[C:2]([OH:4])=[O:3].[CH2:7]([C:10]1[N:23]([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33]C=3)=[C:27](C(OC(C)(C)C)=O)[CH:26]=2)[C:13]2[CH:14]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[NH:15][CH2:16][CH2:17][C:12]=2[N:11]=1)[CH2:8][CH3:9].[C:44](Cl)(=[O:47])[CH2:45][CH3:46]>>[CH2:7]([C:10]1[N:23]([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][C:1]=3[C:2]([O:4][C:25]([CH3:30])([CH3:26])[CH3:24])=[O:3])=[CH:27][CH:26]=2)[C:13]2[CH:14]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[N:15]([C:44](=[O:47])[CH2:45][CH3:46])[CH2:16][CH2:17][C:12]=2[N:11]=1)[CH2:8][CH3:9]