Ethyl chloroformate → HCID 19933000, compound

HRID 1655121Notes

Reaction equation

[C:1](O)(=O)[C:2]([OH:4])=[O:3].[CH2:7]([C:10]1[N:23]([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([C:31]3C=[CH:35][CH:34]=[CH:33][CH:32]=3)=[C:27](C(OC(C)(C)C)=O)[CH:26]=2)[C:13]2[CH:14]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[NH:15][CH2:16][CH2:17][C:12]=2[N:11]=1)[CH2:8][CH3:9].Cl[C:45]([O:47][CH2:48][CH3:49])=[O:46]>>[CH2:7]([C:10]1[N:23]([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][C:1]=3[C:2]([O:4][C:25]([CH3:30])([CH3:26])[CH3:24])=[O:3])=[CH:27][CH:26]=2)[C:13]2[CH:14]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[N:15]([C:45]([O:47][CH2:48][CH3:49])=[O:46])[CH2:16][CH2:17][C:12]=2[N:11]=1)[CH2:8][CH3:9]

Participants

Reactant 2

HCID 10928Ethyl chloroformate

HCID 20076809HCID 20076809, compound

Product 1

HCID 19933000HCID 19933000, compoundYield 169.1%

Procedure

The compound obtained in Example 62 (1.00 g) is treated in the same manner as in Example 64 with using ethyl chloroformate (0.27 g) instead of acetic anhydride to give ethyl 2-n-propyl-5-ethoxycarbonyl-3-[2'-(t-butoxycarbonyl)biphenyl-4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]-pyridine-4-carboxylate (0.82 g) as a white foam.

Sources & evidence

ORD record: ord-52090f0e767e410195c721b3c2ff683f
Source dataset: uspto-grants-1995_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05409936

Reaction notes

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