Methyl 4'-(bromomethyl)biphenyl-2-carboxylate → HCID 19932971, compound

HRID 1655135Notes

Reaction equation

HRID 1655135 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][C:11]1[N:12]=[C:13]([CH2:16][CH2:17][CH2:18][CH3:19])[NH:14][CH:15]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[C:29]([C:34]([O:36][CH3:37])=[O:35])=[CH:30][CH:31]=[CH:32][CH:33]=2)=[CH:24][CH:23]=1>>[CH2:16]([C:13]1[N:14]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[C:34]([O:36][CH3:37])=[O:35])=[CH:24][CH:23]=2)[CH:15]=[C:11]([CH2:10][CH2:9][NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[N:12]=1)[CH2:17][CH2:18][CH3:19]

Participants

3

Reactant 2

HCID 11012181Methyl 4'-(bromomethyl)biphenyl-2-carboxylateHCID 178441649HCID 178441649, compound

Product 1

HCID 19932971HCID 19932971, compoundYield 48%

Procedure

4-[2-(t-Butoxycarbonylamino)ethyl]-2-n-butylimidazole (3.0 g) and methyl 4'-bromomethylbiphenyl-2-carboxylate (3.75 g) are treated in the same manner as in Example 1 to give 2-n-butyl-4-(2-t-butoxycarbonylaminoethyl)-1-[2'-methoxycarbonylbiphenyl-4-yl]methylimidazole (2.65 g) as an oil.

Sources & evidence

ORD record
ord-3bf52c1d9e99486fa3a7b99784eef101
Source dataset
uspto-grants-1995_04
Patent number
US05409936

Reaction notes

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