Tetrahydrofuran → HCID 53994676, compound

Participants

Reaction Steps

By the method of Example 10, 0.49 g (0.0012 mole) of 3-[[4-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-pyrazol-5-yl]acrylic acid chloride, 0.25 g (0.0015 mole) of phenylmethanesulfonamide, and 0.038 g (0.0016 mole) of sodium hydride were reacted in 10 mL of tetrahydrofuran, yielding 0.35 g of N-phenylmethanesulfonyl-3-[4-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-pyrazol-5-yl]acrylamide as a solid; m.p. 178°-183° C. The nmr spectrum was consistent with the proposed structure.

Provenance & Evidence