Thionyl Chloride → 3-Chloro-2-chloromethyl-4-morpholin-4-yl-pyridinium chloride

Participants

Reaction Steps

Thionyl chloride (3 ml) in chloroform (25 ml) was added dropwise to a solution of 4 -morpholino-3 -chloro-2 -hydroxymethylpyridine (3.09 g) in chloroform (25 ml) cooled in an ice/salt bath. Following the addition the ice bath was removed and the mixture stirred for a further 1.5 hours. The volume of the solution was reduced and ether added to give 4 -morpholino-3 -chloro-2 -chloromethylpyridine hydrochloride, 3.77 g, m.p. 200°-2°.

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