Dimethylamine → HCID 19791196, compound

HRID 1655212Notes

Reaction equation

HRID 1655212 reaction equation
[Cl:1][C:2]1[C:3]([CH2:10][OH:11])=[N:4][CH:5]=[C:6]([CH3:9])[C:7]=1Cl.[CH3:12][NH:13][CH3:14]>C(O)C>[CH3:12][N:13]([CH3:14])[C:7]1[C:6]([CH3:9])=[CH:5][N:4]=[C:3]([CH2:10][OH:11])[C:2]=1[Cl:1]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 19791150HCID 19791150, compound

Product 1

HCID 19791196HCID 19791196, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
2000 °C

Procedure

3,4 -dichloro-5 -methyl-2 -hydroxymethylpyridine (4 g) was dissolved in 33 % dimethylamine in ethanol (11 ml), placed in a sealed vessel and heated to 2000° C. for 4 hours. On cooling, the reaction mixture was evaporated under reduced presure and the residue dissolved in water (15 ml) and ether extracted. Etherial extracts were dried (K2CO3 ), filtered and stripped to yield 4 -dimethylamino-3 -chloro-5 -methyl-2 -hydroxymethylpyridine, 4.08 g as an oil.

Workup

  1. customplaced in a sealed vessel
  2. temperatureOn cooling
  3. customthe reaction mixture was evaporated under reduced presure
  4. dissolutionthe residue dissolved in water (15 ml)
  5. extractionether extracted
  6. dry with materialEtherial extracts were dried (K2CO3 )
  7. filtrationfiltered

Sources & evidence

ORD record
ord-1710ec3cb6394729bfec9f19484f7859
Source dataset
uspto-grants-1993_10
Patent number
US05250527

Reaction notes

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