HCID 86747255, compound → HCID 178488144, compound

HRID 1655216Notes

Reaction equation

HRID 1655216 reaction equation
[N:1]1([C:7]2[C:12]([Br:13])=[CH:11][N:10]=[C:9]([CH2:14][S:15][C:16]3[NH:20][C:19]4[CH:21]=[CH:22][C:23]([O:25][CH3:26])=[CH:24][C:18]=4[N:17]=3)[CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[O:27]1CCN(C2C3N(Cl)CN(SCC4C=CC=CN=4)C=3C=CC=2OC)CC1>>[N:1]1([C:7]2[C:12]([Br:13])=[CH:11][N:10]=[C:9]([CH2:14][S:15]([C:16]3[NH:20][C:19]4[CH:21]=[CH:22][C:23]([O:25][CH3:26])=[CH:24][C:18]=4[N:17]=3)=[O:27])[CH:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 86747255HCID 86747255, compoundHCID 178488120HCID 178488120, compound

Product 1

HCID 178488144HCID 178488144, compound

Procedure

Substituting 2-(4-piperidino-5-bromo-2-pyridylmethylthio)-5-methoxy-(1H)-benzimidazole (3.83 g) for 2-(4-morpholino-3-chloro-2-pyridylmethylthio-5-methoxy-(1H)-benzimidazole and using corresponding molar proportions of the other reagents in the method of Example 4 gave after chromatography (silica gel, chloroform:methanol-ammonia) 2-(4-piperidino-5-bromo-2-pyridylmethylsulphinyl)-5-methoxy-(1H)-benzimidazole, 3.15 g, m.p. 114°-8° C., from ether.

Sources & evidence

ORD record
ord-64e0ae91db8f42969af39b279075c998
Source dataset
uspto-grants-1993_10
Patent number
US05250527

Reaction notes

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