反应详情

5N NaOH (3.39 ml) was added dropwise to a stirred solution of 2-chloromethyl-3-fluoro-4-morpholinopyridine hydrochloride (2.06 g) and 5-methoxy-(1H)-benzimidazole-2-thiol (1.39 g) in ethanol (35 ml). After 3 hours excess solvent was removed and the residue treated with water (80 ml) and extracted with dichloromethane. The extracts were washed with water, dried (K2CO3), excess solvent removed and the residue crystallised from ethyl acetate to yield 2-(4-morpholino-3-fluoro-2-pyridylmethylthio)-5-methoxy-(1H)-benzimidazole (2.16 g) m.p. 121°-123°.

1. customAfter 3 hours excess solvent was removed
2. additionthe residue treated with water (80 ml)
3. extractionextracted with dichloromethane
4. washThe extracts were washed with water
5. dry with materialdried (K2CO3), excess solvent
6. customremoved
7. customthe residue crystallised from ethyl acetate