Diethyl Ether → HCID 19791253, compound

HRID 1655236Notes

Reaction equation

HRID 1655236 reaction equation
S(Cl)([Cl:3])=O.O[C:6]1[C:11]([CH3:12])=[C:10]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:9]([F:19])=[CH:8][N:7]=1.CCOCC.[CH:25](Cl)(Cl)[Cl:26]>>[ClH:3].[Cl:26][CH2:25][C:6]1[C:11]([CH3:12])=[C:10]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:9]([F:19])=[CH:8][N:7]=1

Participants

5

Reactant 4

HCID 3283Diethyl EtherHCID 6212Chloroform2×HCID 24386Thionyl ChlorideHCID 178431772HCID 178431772, compound

Product 1

HCID 19791253HCID 19791253, compound

Procedure

Thionyl chloride (0.73 ml) in chloroform (5 ml, alumina dried) was added dropwise to a stirred and cooled solution of 2-hydroxy-3-methyl-4-morpholino-5-fluoro pyridine (0.75 g) in chloroform (15 ml). After 2 hours at room temperature the solution was reduced in volume and ether added. The precipitate was filtered off, washed and dried to give 2-chloromethyl-3-methyl-4-morpholino-5-fluoropyridine hydrochloride (0.6 g) m.p.148°-156°.

Workup

  1. additionadded
  2. filtrationThe precipitate was filtered off
  3. washwashed
  4. customdried

Sources & evidence

ORD record
ord-024b23cfc37547c49cea9fb3df8af19e
Source dataset
uspto-grants-1993_10
Patent number
US05250527

Reaction notes

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