Dichloromethane → HCID 19791567, compound

Participants

Reaction Steps

56.5 g (0.32 mol) of the compound from Example I are stirred in 400 ml of anhydrous dichloromethane containing 277 ml (3.8 mol) of thionyl chloride overnight at 20°-30° C. Subsequently, dichloromethane and unreacted thionyl chloride are removed in a water pump vacuum at 20°-30° C. The residue is partitioned between dichloromethane and aqueous saturated sodium bicarbonate solution. The organic phase is separated off, dried and evaporated in vacuo. 59.3 g of the crude title compound are obtained as an oil.

Provenance & Evidence