HCID 19791567, compound → HCID 19791564, compound

HRID 1655279Notes

Reaction equation

HRID 1655279 reaction equation
Cl[CH:2]([C:6]1[C:7]([O:12][CH3:13])=[N:8][CH:9]=[CH:10][CH:11]=1)[CH2:3][CH:4]=[CH2:5]>CO.[Zn]>[CH2:2]([C:6]1[C:7]([O:12][CH3:13])=[N:8][CH:9]=[CH:10][CH:11]=1)[CH2:3][CH:4]=[CH2:5]

Participants

4

Reactant 1

HCID 19791567HCID 19791567, compound

Product 1

HCID 19791564HCID 19791564, compoundYield 23%

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 887MethanolSolvent

Procedure

A total of 71.4 g of zinc (copper-activated) are added to 118.5 g (0.54 mol) of the compound from Example II in 1000 ml of anhydrous methanol, and the mixture is refluxed for 2 hours. The precipitate is filtered off, and the filtrate is subsequently evaporated in vacuo. Fractional distillation of the residue produces 20.0 g of the title compound having b.p. 96° C./20 mmHg.

Workup

  1. temperaturethe mixture is refluxed for 2 hours
  2. filtrationThe precipitate is filtered off
  3. customthe filtrate is subsequently evaporated in vacuo
  4. distillationFractional distillation of the residue

Sources & evidence

ORD record
ord-3f3d476fc721426c8e189defd497e179
Source dataset
uspto-grants-1993_10
Patent number
US05250540

Reaction notes

Loading…