Sodium Bicarbonate → (S)-Methyl 3-([1,1'-biphenyl]-4-yl)-2-aminopropanoate

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Reaction Steps

To a suspension of (S)-2-amino-3-(biphenyl-4-yl)-propionic acid methyl ester hydrochloride (J. Org. Chem., 1992, 57, 379; 10 g, 34.3 mmol) in water (200 mL) is added solid sodium bicarbonate (3.17 g, 37.7 mmol). The mixture is stirred for 30 minutes and then extracted with ether (3×80 mL). The combined organic phases are washed with brine (50 mL) and then dried over anhydrous magnesium sulfate. Evaporation of the solvent in vacuo affords (S)-2-amino-3-(biphenyl-4-yl)-propionic acid methyl ester as a white solid.

Provenance & Evidence